I2-Secretase: its biology as a therapeutic target in diseases.

... cell death. There is increasing evidence that changes in BACE1 activity are involved in many diseases, such as Alzheimer's disease (AD), schizophrenia, epileptic behavior, and others. However, a deeper understanding of the molecular biology of BACE1 ...

http://www.citeulike.org/user/cdsouthan/article/12225157