African-Americans with a variant of the ABCA7 gene have almost double the risk of developing late-onset Alzheimer's disease compared with African-Americans who lack the variant.
http://www.eurekalert.org/pub_releases/2013-04/cumc-nga040413.php
http://www.eurekalert.org/pub_releases/2013-04/cumc-nga040413.php
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